MCQOPTIONS
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MCQOPTIONS
This section includes 15 Mcqs, each offering curated multiple-choice questions to sharpen your Biotechnology knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Heroin with pKa 7.8 will be in which form in intestinal pH? |
| A. | Ionized form mostly |
| B. | Unionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» C. Half ionized and half no ionized | |
| 2. |
All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma. |
| A. | True |
| B. | False |
| Answer» C. | |
| 3. |
Nitrazepam a weak base, will be in which form in the stomach? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» B. Non-ionized form mostly | |
| 4. |
Ibuprofen a weak acid, in the stomach will be present in which of the given form? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» C. Half ionized and half no ionized | |
| 5. |
What should be the range of oil/water partition coefficient of any drug? |
| A. | 1-2 |
| B. | 3-4 |
| C. | 2-3 |
| D. | 1-3 |
| Answer» B. 3-4 | |
| 6. |
Example of a drug which has PKa > 11 is ________ |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Mecamylamine |
| Answer» E. | |
| 7. |
Which one of these is not an example of a basic drug with pKa range 5-11? |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Chloroquine |
| Answer» B. Imipramine | |
| 8. |
Which one of these is an example of a strong acid drug? |
| A. | Diazepam |
| B. | Ibuprofen |
| C. | Cromolyn |
| D. | Aspirin |
| Answer» D. Aspirin | |
| 9. |
Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 10. |
What is the pH range of the intestine? |
| A. | 4-5 |
| B. | 1-3 |
| C. | 1-8 |
| D. | 5-8 |
| Answer» E. | |
| 11. |
What is the pH range of the stomach? |
| A. | 1-4 |
| B. | 5-8 |
| C. | 1-3 |
| D. | 1-8 |
| Answer» D. 1-8 | |
| 12. |
Which of the following equations correct for Henderson-Hasselbach equation for weak bases? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» E. | |
| 13. |
Which of the following equations correct for Henderson-Hasselbach equation for weak acids? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» D. PH = pKa + log (Unionized drug concentration /Ionized drug concentration) | |
| 14. |
If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug. |
| A. | True |
| B. | False |
| Answer» C. | |
| 15. |
According to the pH-partition hypothesis which one of the given options doesn’t govern the absorption? |
| A. | The molecular size of the drug |
| B. | PH at the absorption site |
| C. | Lipid solubility of unionized drugs |
| D. | Dissociation constant |
| Answer» B. PH at the absorption site | |