MCQOPTIONS
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MCQOPTIONS
This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Molecular Biology knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
The first miRNA was identified in C. elegans named __________ |
| A. | Lin-2 |
| B. | RISC |
| C. | Lin-4 |
| D. | DICER |
| Answer» D. DICER | |
| 2. |
The miRNAs are transcribed from non-protein encoding genes and are typically __________ nucleotides long. |
| A. | 10 – 15 |
| B. | 12 – 15 |
| C. | 18 – 20 |
| D. | 20 – 25 |
| Answer» E. | |
| 3. |
Which of the following RNAs can induce gene silencing? |
| A. | miRNA |
| B. | snoRNA |
| C. | ssRNA |
| D. | ncRNA |
| Answer» B. snoRNA | |
| 4. |
Binding of siRNA to the DNA does not lead to __________ |
| A. | Chromatin remodeling |
| B. | Promoter unavailability |
| C. | Transcriptional inhibition |
| D. | Triple helix formation |
| Answer» E. | |
| 5. |
The RNAi mediated gene silencing includes the binding of siRNA to form a complex with the target gene called RISC. |
| A. | True |
| B. | False |
| Answer» C. | |
| 6. |
BINDING_OF_SIRNA_TO_THE_DNA_DOES_NOT_LEAD_TO___________?$ |
| A. | Chromatin remodeling |
| B. | Promoter unavailability |
| C. | Transcriptional inhibition |
| D. | Triple helix formation |
| Answer» E. | |
| 7. |
The miRNAs are transcribed from non-protein encoding genes and are typically __________ nucleotides long.$ |
| A. | 10 – 15 |
| B. | 12 – 15 |
| C. | 18 – 20 |
| D. | 20 – 25 |
| Answer» E. | |
| 8. |
Which_of_the_following_RNAs_can_induce_gene_silencing?$ |
| A. | miRNA |
| B. | snoRNA |
| C. | ssRNA |
| D. | ncRNA |
| Answer» B. snoRNA | |
| 9. |
Stem loop precursors are generally seen in which of the following? |
| A. | siRNA |
| B. | miRNA |
| C. | piRNA |
| D. | Both siRNA and miRNA |
| Answer» C. piRNA | |
| 10. |
piRNAs are synthesized in a Dicer dependent mechanism. |
| A. | True |
| B. | False |
| Answer» C. | |
| 11. |
Inactive miRNA undergoes how many cleavages before incorporation into the RISC complex? |
| A. | 0 |
| B. | 1 |
| C. | 2 |
| D. | 3 |
| Answer» D. 3 | |
| 12. |
The_first_miRNA_was_identified_in_C._elegans_named___________ |
| A. | Lin-2 |
| B. | RISC |
| C. | Lin-4 |
| D. | DICER |
| Answer» D. DICER | |
| 13. |
If the siRNA is a complete homolog of the target mRNA sequences what is the net result? |
| A. | Double helix formation |
| B. | Translation inhibition |
| C. | Chromatin modification |
| D. | mRNA degradation |
| Answer» E. | |
| 14. |
The RNAi mediated gene silencing is an ATP-dependent procedure. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 15. |
The RNAi mediated gene silencing includes the binding of siRNA to form a complex with the target gene called RISC. . |
| A. | True |
| B. | False |
| Answer» C. | |
| 16. |
Which of the following pathways involve the Dicer for gene silencing? |
| A. | Chromatin modification |
| B. | Structural gene triple helix formation |
| C. | DNA polymerase binding |
| D. | RNA polymerase binding |
| Answer» B. Structural gene triple helix formation | |
| 17. |
Dicer is __________ |
| A. | DNAse-like enzyme |
| B. | RNAse-like enzyme |
| C. | An endonuclease |
| D. | An exonuclease |
| Answer» C. An endonuclease | |
| 18. |
Introduction of ds DNA can repress gene expression. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 19. |
Which of the following is not the handiwork of siRNA? |
| A. | Translational inhibition |
| B. | mRNA destruction |
| C. | Base dimerization |
| D. | Promoter silencing |
| Answer» D. Promoter silencing | |
| 20. |
siRNA are produced by __________ |
| A. | Transcription |
| B. | DNA damage |
| C. | RNA damage |
| D. | Enzymatic action |
| Answer» E. | |