Which of the following rule belongs to optimization of the two-phase system for enzyme-catalyzed reactions?

• A. The difference between the Log P values of the products and the organic phase should be as small as possible
• B. Allows to be used with low molecular weight hydrophilic coenzymes with the assistance of a coenzyme regenerating process
• C. Allowing efficient and continuous use of biphasic PBRs as long as the moving organic phase is saturated with water
• D. Allowing efficient and continuous use of biphasic PBRs