MCQOPTIONS
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MCQOPTIONS
This section includes 10 Mcqs, each offering curated multiple-choice questions to sharpen your Biochemistry knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Migration of cancerous cells from the site of origin to other part of the body forming secondary tumors is called ___________ |
| A. | Diapedesis |
| B. | Metastasis |
| C. | Proliferation |
| D. | Apoptosis |
| Answer» C. Proliferation | |
| 2. |
Which of the following about Rb tumor suppressor protein is correct? |
| A. | It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received |
| B. | It is activated when phosphorylated by Cdk |
| C. | It is a transcription factor |
| D. | When a mitogenic signal is received, it binds the transcription factor E2F and thus stimulates the cell to enter S phase |
| Answer» B. It is activated when phosphorylated by Cdk | |
| 3. |
The mutation which cannot give rise to an oncogene? |
| A. | Addition or deletion of a base producing a nonsense message and an inactive protein product |
| B. | A point mutation changing just one amino acid in protein product |
| C. | A translocation, putting gene under control of strong promoter producing over expression |
| D. | A point mutation producing stop codon, premature termination |
| Answer» B. A point mutation changing just one amino acid in protein product | |
| 4. |
The characteristic of malignant other than a benign tumor is? |
| A. | Undergoes metastasis |
| B. | Develops blood supply |
| C. | Cell divides an unlimited number of times |
| D. | Grows without needing a growth signal |
| Answer» B. Develops blood supply | |
| 5. |
Which property of p53 enables it to prevent the development of cancer? |
| A. | It is a transcription factor that causes protein production which stimulates the cell cycle |
| B. | It prevents replication of cells with damaged DNA |
| C. | It prevents cells from triggering apoptosis |
| D. | It stimulates synthesis of DNA repair enzymes that replace telomere sequence lost during cell division |
| Answer» C. It prevents cells from triggering apoptosis | |
| 6. |
How does Ras oncogene contribute to cancers? |
| A. | It codes for an anti-apoptotic protein, produced in abnormally large amounts |
| B. | It codes for a GTPase switch protein, which in its mutated form cannot be switched off |
| C. | It codes for a transcription factor produced abnormally in large amounts |
| D. | A growth factor that is continually active is encoded in its truncated form |
| Answer» C. It codes for a transcription factor produced abnormally in large amounts | |
| 7. |
Which of the following could be coded by a tumor-supressor gene? |
| A. | A protein that helps prevent progression through cell cycle |
| B. | A protein that helps prevent apoptosis |
| C. | A protein that codes for a DNA repair enzyme |
| D. | A protein that forms part of a growth factor signaling pathway |
| Answer» B. A protein that helps prevent apoptosis | |
| 8. |
Programmed cell death is termed as ___________ |
| A. | Metastasis |
| B. | Apoptosis |
| C. | Proliferation |
| D. | Mitotic termination |
| Answer» C. Proliferation | |
| 9. |
Oncogenes do not encode for ___________ |
| A. | Trans-membrane protein receptors |
| B. | Growth factors |
| C. | DNA-dependent RNA polymerase |
| D. | Cytoplasmic G-proteins and protein kinases |
| Answer» D. Cytoplasmic G-proteins and protein kinases | |
| 10. |
Proto-oncogenes can be transformed to oncogenes by all of the following mechanisms except _____________ |
| A. | Elimination of their start signals for translation |
| B. | During a viral infection cycle |
| C. | Chromosomal rearrangements |
| D. | Chemically induced mutagenesis |
| Answer» B. During a viral infection cycle | |