MCQOPTIONS
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MCQOPTIONS
This section includes 18 Mcqs, each offering curated multiple-choice questions to sharpen your Biochemistry knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
An autoimmune disease is |
| A. | AIDS |
| B. | Measles |
| C. | Lupus |
| D. | Mumps |
| Answer» D. Mumps | |
| 2. |
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced |
| A. | alternative complement activation. |
| B. | CD8 T cell-mediated cytotoxicity |
| C. | macrophage activation to vesicular pathogens |
| D. | IgG synthesis |
| Answer» B. CD8 T cell-mediated cytotoxicity | |
| 3. |
To treat HIV infections using drugs, the major problem is that |
| A. | the drugs that are good inhibitors cannot by synthesized |
| B. | the drugs interfere with normal digestion |
| C. | the virus particles with altered (mutant) proteases arise |
| D. | the drugs are rapidly degraded |
| Answer» D. the drugs are rapidly degraded | |
| 4. |
The primary reason for AIDS, a deadly disease is that it |
| A. | is caused by a virus |
| B. | is caused by a bacterium |
| C. | destroys key components of the body's internal defense system |
| D. | causes a breakdown of the body's inflammatory response |
| Answer» D. causes a breakdown of the body's inflammatory response | |
| 5. |
Infants are most susceptible to bacterial infection due to low circulating levels of IgG |
| A. | in utero (before birth) |
| B. | at 0-3 months of age |
| C. | at 3-12 months of age |
| D. | at 12-24 months of age |
| Answer» D. at 12-24 months of age | |
| 6. |
The chemical, typically released by the body in an allergic response is |
| A. | histamine |
| B. | allergens |
| C. | antihistamines |
| D. | perforins |
| Answer» B. allergens | |
| 7. |
A selective IgA deficiency would be expected to result in problems with |
| A. | bacterial infections |
| B. | infections following dental work due to bacteria entering the bloodstream |
| C. | mucosal pathogens |
| D. | pathogens which can survive inside macrophages |
| Answer» D. pathogens which can survive inside macrophages | |
| 8. |
An example of an immunodeficiency disorder is |
| A. | thyroiditis |
| B. | rheumatic fever |
| C. | systemic lupus erythematosus |
| D. | AIDS |
| Answer» E. | |
| 9. |
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be |
| A. | activation of B cells by T-independent antigens |
| B. | failure of B cells to provide co-stimulation for Th2 activation |
| C. | failure of Th2 cells to provide co-stimulation for B cell isotype switching |
| D. | failure of Th2 cells to provide co-stimulation for B cell proliferation |
| Answer» D. failure of Th2 cells to provide co-stimulation for B cell proliferation | |
| 10. |
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a |
| A. | knock-out mouse for RAG-1 and RAG-2 |
| B. | knock-out mouse for a thymus |
| C. | nude mouse |
| D. | recombinant mouse for CD3 |
| Answer» D. recombinant mouse for CD3 | |
| 11. |
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with |
| A. | CTL killing of viruses |
| B. | dendritic cell activation to become a mature APC |
| C. | infected cell processing of virus peptides |
| D. | macrophage intracellular killing of bacteria |
| Answer» E. | |
| 12. |
Difficulties with somatic gene therapy arise from all of the following except |
| A. | GVHD caused by mature T cells in the transplanted cells |
| B. | inserting a gene so that it will function properly |
| C. | limited life span of more mature hematopoietic cells |
| D. | transducing genetic material into stem cells |
| Answer» B. inserting a gene so that it will function properly | |
| 13. |
Retinoblastoma is due to a mutation in a |
| A. | kinase |
| B. | tumor supressor |
| C. | cyclin |
| D. | viral gene |
| Answer» C. cyclin | |
| 14. |
A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind |
| A. | Leu or Ileu |
| B. | His or Pro |
| C. | Tyr or Phe |
| D. | Ser or Thr |
| Answer» D. Ser or Thr | |
| 15. |
The HIV virus infects primarily |
| A. | brain cells |
| B. | cells in the immune system |
| C. | red blood cells |
| D. | liver cells |
| Answer» C. red blood cells | |
| 16. |
Specific translocations are associated with |
| A. | colon cancer |
| B. | breast cancer |
| C. | pancreatic cancer |
| D. | some leukemias |
| Answer» E. | |
| 17. |
Which of the Rous sarcoma virus has a homologous cellular protein? |
| A. | c-src |
| B. | v-src |
| C. | v-ha-src |
| D. | v-ha-ras |
| Answer» B. v-src | |
| 18. |
Bone marrow given to an infant with SCID must |
| A. | be irradiated to eliminate GVHD |
| B. | contain mature T cells that can begin making immune responses immediately |
| C. | come from a donor that shares some MHC alleles with the recipient |
| D. | come from one of the child's parents |
| Answer» D. come from one of the child's parents | |