MCQOPTIONS
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MCQOPTIONS
This section includes 15 Mcqs, each offering curated multiple-choice questions to sharpen your Protein Engineering knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
APC inactivates FVIIIa by proteolytic cleavage at which of the following sites? |
| A. | R313 and/or R512 |
| B. | R454 and/or R565 |
| C. | R234 and/or R554 |
| D. | R336 and/or R562 |
| Answer» E. | |
| 2. |
How many alternatively spliced transcripts are produced by factor VIII gene? |
| A. | Five |
| B. | Seven |
| C. | Three |
| D. | Two |
| Answer» E. | |
| 3. |
The potency of gene therapy vectors can be enhanced by using bioengineered extended half-life (EHL) FVIII or FIX fusion proteins as transgenes. |
| A. | False |
| B. | True |
| Answer» C. | |
| 4. |
Removing which of the following enzyme cleavage site impedes the A2 dissociation? |
| A. | Rennin |
| B. | Pepsin |
| C. | Furin |
| D. | Thrombin |
| Answer» E. | |
| 5. |
Small changes in the amino acid sequence of proteins can have a profound effect on their immunogenicity. |
| A. | False |
| B. | True |
| Answer» C. | |
| 6. |
Which of the following can inactivate the activated FVIII? |
| A. | Inactivated protein B |
| B. | Activated protein B |
| C. | Inactivated protein C |
| D. | Activated protein C |
| Answer» E. | |
| 7. |
Furin Cleavage is necessary for FVIII biological functions. |
| A. | True |
| B. | False |
| Answer» C. | |
| 8. |
Which of the following enzyme cleaves fibrinogen into fibrin which polymerizes and crosslinks (using factor VIII) into a blood clot? |
| A. | Pepsin |
| B. | Lipase |
| C. | Furin |
| D. | Thrombin |
| Answer» E. | |
| 9. |
Which of the following factors require LMAN1-facilitated transport from the ER to the Golgi? |
| A. | FV and FVI |
| B. | FVII and FVI |
| C. | FVI and FVIII |
| D. | FVIII and FV |
| Answer» E. | |
| 10. |
Protein-engineered bypassing agents have the potential to treat bleeding in haemophilia patients with inhibitors. |
| A. | False |
| B. | True |
| Answer» C. | |
| 11. |
The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP enhances FVIII secretion. |
| A. | True |
| B. | False |
| Answer» C. | |
| 12. |
Elimination of disulfide bond between which two amino acid residues within the A3 domain increases FVIII secretion by 2-fold? |
| A. | C1414 and C1456 |
| B. | C1123 and C1158 |
| C. | C1785 and C1798 |
| D. | C1899 and C1903 |
| Answer» E. | |
| 13. |
Which of the following catalyzes the conversion of prothrombin to thrombin? |
| A. | Platelets |
| B. | Fibrin |
| C. | Pectinase |
| D. | Thromboplastin |
| Answer» E. | |
| 14. |
Which of the following are a successful acute and prophylactic protein bypassing agent for haemophilia with inhibitors? |
| A. | Recombinant FVIa |
| B. | Recombinant FVa |
| C. | Recombinant FVIIIa |
| D. | Recombinant FVIIa |
| Answer» E. | |
| 15. |
B domain of FVIII is necessary for the clotting activity. |
| A. | True |
| B. | False |
| Answer» C. | |