With Reference to antibiotic resistance all of the following statements are true,Except:

• A. Plasmid mediated resistance is exclusively transmitted vertically
• B. Most common mechanism is production of neutralizing enzymes by bacteria
• C. Alteration of target binding site leads to development of resistance to antibiotics in streptococcus pneumoniae
• D. Complete elimination of target binding site may be the mechanism of resistance in some enterococci against vancomycin