Which among the following statements is NOT true according to the passage.

• A. The protein that targets the immune system is increased during sleep.
• B. A busy workweek doesn't require to make up for the lost sleep.
• C. It's often advisable to get an annual flue shot.
• D. Skimping on shut-eyes slashes the odds of a productive life.
• E. Flue vaccines are made less effective by sleep loss.