A 42-year-old man presented with a 1-month history of altered personality and increased seizure frequency. An MR scan of brain demonstrated an enhancing lesion in the right frontal lobe. Histology revealed a grade 3 oligodendroglioma, with loss of heterozygosity of 1p/19q. What is the most appropriate treatment?

chemoradiation with temozolomide

procarbazine, vincristine and lomustine (PCV)

A 42-year-old man presented with a 1-month history of altered personal

1.	A 42-year-old man presented with a 1-month history of altered personality and increased seizure frequency. An MR scan of brain demonstrated an enhancing lesion in the right frontal lobe. Histology revealed a grade 3 oligodendroglioma, with loss of heterozygosity of 1p/19q. What is the most appropriate treatment?
A.	chemoradiation with temozolomide
B.	cranial irradiation
C.	craniospinal irradiation
D.	procarbazine, vincristine and lomustine (PCV)
E.	temozolomide
Answer» C. craniospinal irradiation

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